INTERACTION BETWEEN PROTEINS AND SYNTHETIC DETERGENTS
نویسندگان
چکیده
منابع مشابه
Interaction between Proteins and Synthetic Detergents
Attempts have been made to explain the action of certain proteindenaturing agents, such as organic solvents, urea, guanidine halides, and salicylates, in terms of (a) physical solvent effects (cf. (4)) or (b) unspecified intermediary combination between denaturant and protein (cf. (5)). Recent work has shown that the denaturing effect of guanidine hydrochloride, one of the most powerful denatur...
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All the synthetic detergents and bile salts I have tried denature proteins such as hemoglobin and egg albumin at the isoelectric point 1 and keep the denatured isoelectric protein in solution. Some detergents in sufficiently high concentration can prevent the precipitation of denatured protein by trichloracetic acid, tungstic acid, and acid ferric sulfate. In fact, the origin of the present inv...
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The bactericidal and bacteriostatic actions of soaps have been recognized for many years. Detailed studies by Eggerth (1) on the germicidal action of soaps have shown the importance of such factors as length of hydrocarbon chain, chemical configuration, effect of hydrogen ion concentration, effect of serum, etc. Avery (2) demonstrated the selective germicidal action of soap on microorganisms, a...
متن کاملInteraction of membrane proteins and lipids with solubilizing detergents.
Detergents are indispensable in the isolation of integral membrane proteins from biological membranes to study their intrinsic structural and functional properties. Solubilization involves a number of intermediary states that can be studied by a variety of physicochemical and kinetic methods; it usually starts by destabilization of the lipid component of the membranes, a process that is accompa...
متن کاملSimulation studies of the interactions between membrane proteins and detergents.
Interactions between membrane proteins and detergents are important in biophysical and structural studies and are also biologically relevant in the context of folding and transport. Despite a paucity of high-resolution data on protein-detergent interactions, novel methods and increased computational power enable simulations to provide a means of understanding such interactions in detail. Simula...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1945
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)51317-5